Estimation of Genetic Parameters for Peak Yield, Yield and Persistency Traits in Murciano-Granadina Goats Using Multi-Traits Models

This paper studies parameters of a lactation curve such as peak yield (PY) and persistency (P), which do not conform to the usual selection criteria in the Murciano-Granadina (MG) breed, but are considered to be an alternative to benefit animal welfare without reducing production. Using 315,663 production records (of 122,883 animals) over a period of 24 years (1990–2014), genetic parameters were estimated with uni-, bi- and multivariate analysis using multiple trait derivative free restricted maximum likelihood (MTDFREML). The heritability (h2)/repeatability (re) of PY, yield (Y) and P was estimated as 0.13/0.19, 0.16/0.25 and 0.08/0.09 with the uni-trait and h2 of bi- and multi-traits analysis ranging from 0.16 to 0.17 of Y, while that of PY and Y remained constant. Genetic correlations were high between PY–Y (0.94 ± 0.011) but low between PY–P (–0.16 ± 0.054 to –0.17 ± 0.054) and between Y–P (–0.06 ± 0.058 to –0.05 ± 0.058). Estimates of h2/re were low to intermediate. The selection for Y–PY or both can be implemented given the genetic correlation between these traits. PY–P and Y–P showed low to negligible correlation values indicating that if these traits are implemented in the early stages of evaluation, they would not be to the detriment of PY–Y. The combination of estimated breeding values (EBVs) for all traits would be a good criterion for selection

Structure and application of antifreeze proteins from Antarctic bacteria

Indexación: Web of Science; Scopus.Background: Antifreeze proteins (AFPs) production is a survival strategy of psychrophiles in ice. These proteins have potential in frozen food industry avoiding the damage in the structure of animal or vegetal foods. Moreover, there is not much information regarding the interaction of Antarctic bacterial AFPs with ice, and new determinations are needed to understand the behaviour of these proteins at the water/ice interface. Results: Different Antarctic places were screened for antifreeze activity and microorganisms were selected for the presence of thermal hysteresis in their crude extracts. Isolates GU1.7.1, GU3.1.1, and AFP5.1 showed higher thermal hysteresis and were characterized using a polyphasic approach. Studies using cucumber and zucchini samples showed cellular protection when samples were treated with partially purified AFPs or a commercial AFP as was determined using toluidine blue O and neutral red staining. Additionally, genome analysis of these isolates revealed the presence of genes that encode for putative AFPs. Deduced amino acids sequences from GU3.1.1 (gu3A and gu3B) and AFP5.1 (afp5A) showed high similarity to reported AFPs which crystal structures are solved, allowing then generating homology models. Modelled proteins showed a triangular prism form similar to β-helix AFPs with a linear distribution of threonine residues at one side of the prism that could correspond to the putative ice binding side. The statistically best models were used to build a protein-water system. Molecular dynamics simulations were then performed to compare the antifreezing behaviour of these AFPs at the ice/water interface. Docking and molecular dynamics simulations revealed that gu3B could have the most efficient antifreezing behavior, but gu3A could have a higher affinity for ice. Conclusions: AFPs from Antarctic microorganisms GU1.7.1, GU3.1.1 and AFP5.1 protect cellular structures of frozen food showing a potential for frozen food industry. Modeled proteins possess a β-helix structure, and molecular docking analysis revealed the AFP gu3B could be the most efficient AFPs in order to avoid the formation of ice crystals, even when gu3A has a higher affinity for ice. By determining the interaction of AFPs at the ice/water interface, it will be possible to understand the process of adaptation of psychrophilic bacteria to Antarctic ice.https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0737-

Synthesizing attractors of Hindmarsh-Rose neuronal systems

In this paper a periodic parameter switching scheme is applied to the Hindmarsh-Rose neuronal system to synthesize certain attractors. Results show numerically, via computer graphic simulations, that the obtained synthesized attractor belongs to the class of all admissible attractors for the Hindmarsh-Rose neuronal system and matches the averaged attractor obtained with the control parameter replaced with the averaged switched parameter values. This feature allows us to imagine that living beings are able to maintain vital behavior while the control parameter switches so that their dynamical behavior is suitable for the given environment.Comment: published in Nonlinear Dynamic

Nivel de información médica sobre diabetes, actitud de los pacientes hacia la enfermedad y su asociación con el nivel de control glucémico

ObjetivoDeterminar el nivel de información y de actitud que sobre su enfermedad tienen pacientes con diabetes tipo 2 (DM2) y su asociación con el nivel de control glucémico.DiseñoEncuesta transversal survey.EmplazamientoDos unidades de medicina familiar.PacientesDoscientos sujetos con DM2.IntervencionesSe aplicaron 2 instrumentos validados para valorar nivel de conocimientos y actitud, y se midió el promedio de las últimas 6 glucemias.Mediciones y resultadosLa calificación global del instrumento de conocimientos fue 58,6 ± 17,9 (escala 0-100). Para el instrumento de actitud fue de 18,9 ± 2,1 (escala 0-35). La calificación de conocimientos del grupo controlado fue de 55,48 ± 16,8, y la del grupo descontrolado de 59,2 ± 18,1. La calificación sobre actitud del grupo controlado fue de 17,8 ± 2,3, y la del grupo descontrolado de 19,1 ± 2 (p = 0,001). El nivel de información proporcionado por el médico familiar fue del 42,9%, por el equipo de salud del 10,2% y por otras fuentes del 6,3%. En cuanto al análisis del grado de actitud y el nivel de información, hubo una mejor actitud cuando la información fue proporcionada por otras fuentes (p < 0,05). Por lo que respecta al porcentaje de información y el control glucémico, el nivel de control fue mejor cuando la información fue proporcionada por el equipo de salud (p < 0,01).ConclusionesEl nivel de información médica sobre diabetes proporcionada por el médico familiar y el equipo de salud es bajo, y sólo en este último caso se asocia a un mejor control glucémico. La actitud es mejor cuando se recibe información sobre diabetes de otras fuentes.ObjectiveTo determine the level of information and attitude that it has more than enough their illness has patient with diabetes type 2 (DM2), and their association with level of glucemic control.DesignCross-sectional.SettingTwo units of family medicine.Patient200 subject with DM2.InterventionsTwo instruments were applied validated to measure, level of knowledge and attitude was measured the average of the last 6 glucaemias.Measurements and resultsThe qualification average of the instrument of knowledge was 58.6 ± 17.9 (it scale 0–100). For the instrument of attitude it was of 18.9 ± 2.1 (it scale 0 at 35). The qualification of knowledge of the controlled group was of 55.48 ± 16.8, and of the uncontrolled group it was of 59.2 ± 18.1. The qualification has more than enough attitude of the controlled group it was of 17.8 ± 2.3, and of the uncontrolled group of 19.1 ± 2, p = 0.001. The proportionate level of information the family doctor was of 42.9%, of the team of health of 10.2% and of other sources of 6.3%. At the analysis of the degree of attitude and the level of information, there was a better attitude when the information was provided by other sources p < 0.05. In the percentage of information and the level of glucemic control, the control level was better when the information was for the team of health p < 0.01.ConclusionsThe level of medical information on diabetes provided by the family doctor and the team of health is low and it doesn't and only this last are associate to better glucemic control. The attitude is better when one receives information of other sources

Integrating process design and control: An application of optimal control to chemical processes

In this paper, the optimal design of process systems generically used in chemical industries is studied. The closely coupled nature of optimal design specification of the equipment, the determination of the optimal process parameters in steady-state, moreover, some issues of the application of optimal control is shown. The solution of the overall optimization problem including (i) optimal design of the equipment and (ii) specification of its optimal control strategy can be found relying on two different design concepts, namely, on the conventionally used sequential or, on the newly emerged simultaneous design approaches. This paper gives the theoretical background of the ideas and presents a comparative summary of the approaches. The two approaches are contrasted to each other in which the effects of the interaction of optimal process design and optimal control is highlighted. A new simultaneous optimization procedure providing economic and operability benefits over the traditional stand-alone approach is proposed. The applicability of the idea is demonstrated by means of a design study carried out for optimal design of a coaxial heat exchanger and a reactive distillation column for the synthesis of ethyl tert butyl ether (ETBE), relying on the benefits of the utilization of optimal control

How do practically trained (student) caregivers in nursing homes learn?:A scoping review

Background and objective: Practically trained (student) caregivers (further: caregivers) make up the majority of care staff in nursing homes (NHs). To keep up with the fast-changing healthcare environment and ensure a high quality of care, it is important to know how to stimulate continuous work-based learning (WBL) among this group. The purpose of the study was to systematically study the scientific literature published to date on (1) how caregivers learn in NHs and (2) what facilitates or impedes their learning. Methods: A scoping review was carried out, systematically searching six scientific databases. A total of 35 studies published from January 2009 to February 2021 were included. Study characteristics, learning mechanisms, facilitators, and barriers to learning were extracted and synthesized. Results: None of the studies specifically focused on how caregivers learn. Yet, we identified various learning mechanisms, and found that learning by theory or supervision was most frequently engaged in. Most learning mechanisms used among the groups in the included studies were planned and formal and developed and initiated by others out of the context. Three main themes were identified among the facilitators and barriers of WBL: individual learning, collective learning, and resources for learning. An interdependency between (sub)themes was found. Conclusions: The way caregivers in NHs learn is understudied. Moreover, both their informal learning and the support they receive to be(come) active learners has been overlooked. As WBL provides caregivers with opportunities to learn within a real-life setting, we suggest more research on informal learning mechanisms

Laparoscopic Upper-pole Nephroureterectomy In Infants

Objective: Report the results of laparoscopic upper-pole nephroureterectomy in infants. Materials and Methods: Six consecutive infants underwent 7 laparoscopic upper-pole nephroureterectomy. Pre and post-operative evaluation included renal sonography, voiding cystourethrogram and renal scintigraphy. All infants showed upper-pole exclusion. Surgery was performed through a transperitoneal approach with full flank position in all infants. Three or 4 ports were used according to the necessity of retracting the liver. The distal ureter was ligated close to the bladder whenever reflux was present and the dysplastic upper-pole was divided with the help of an electrocautery. Data regarding operative time, postoperative use of analgesics, time to resume oral feeding, hospital stay and tubular function were collected and analyzed. Results: All procedures were concluded as planned. Mean operative time was 135 min. One patient underwent staged bilateral upper-pole nephrectomy. There were no complications and the postoperative hospital stay was 48 hours in 5 procedures and 24 hours in 2 procedures. Pain medication was required only in the first day. Renal tubular function showed improvement in half of the cases. Conclusion: Laparoscopic partial nephrectomy is a safe and feasible procedure in infants. Due to the magnification provided by the lenses, a better vision of the structures is achieved, facilitating selective dissection of vascular upper-pole, renal parenchyma and distal ureter. This approach is less damaging to the lower pole, and is associated to low morbidity and a short hospital stay.3318791Peters, C.A., Laparoscopic and robotic approach to genitourinary anomalies in children (2004) Urol Clin North Am, 31, pp. 595-605Robinson, B.C., Snow, B.W., Cartwright, P.C., De Vries, C.R., Hamilton, B.D., Anderson, J.B., Comparison of laparoscopic versus open partial nephrectomy in a pediatric series (2003) J Urol, 169, pp. 638-640Steyaert, H., Valla, J.S., Minimally invasive urologic surgery in children: An overview of what can be done (2005) Eur J Pediatr Surg, 15, pp. 307-313Koyle, M.A., Woo, H.H., Kavoussi, L.R., Laparoscopic nephrectomy in the first year of life (1993) J Pediatr Surg, 28, pp. 693-695Valla, J.S., Breaud, J., Carfagna, L., Tursini, S., Steyaert, H., Treatment of ureterocele on duplex ureter: Upper pole nephrectomy by retroperitoneoscopy in children based on a series of 24 cases (2003) Eur Urol, 43, pp. 426-429Jordan, G.H., Winslow, B.H., Laparoendoscopic upper pole partial nephrectomy with ureterectomy (1993) J Urol, 150, pp. 940-943Horowitz, M., Shah, S.M., Ferzli, G., Syad, P.I., Glassberg, K.I., Laparoscopic partial upper pole nephrectomy in infants and children (2001) BJU Int, 87, pp. 514-516Gill, I.S., Delworth, M.G., Munch, L.C., Laparoscopic retroperitoneal partial nephrectomy (1994) J Urol, 152, pp. 1539-1542Borzi, P.A., A comparison of the lateral and posterior retroperitoneoscopic approach for complete and partial nephroureterectomy in children (2001) BJU Int, 87, pp. 517-520Desgrandchamps, F., Gossot, D., Jabbour, M.E., Meria, P., Teillac, P., Le Duc, A., A 3 trocar technique for transperitoneal laparoscopic nephrectomy (1999) J Urol, 161, pp. 1530-1532Hulbert, W.C., Rabinowitz, R., Prenatal diagnosis of duplex system hydronephrosis: Effect on renal salvage (1998) Urology, 51, pp. 23-26El-Ghoneimi, A., Farhat, W., Bolduc, S., Bagli, D., McLorie, G., Khoury, A., Retroperitoneal laparoscopic vs open partial nephroureterectomy in children (2003) BJU Int, 91, pp. 532-535Jednak, R., Kryger, J.V., Barthold, J.S., Gonzalez, R., A simplified technique of upper pole heminephrectomy for duplex kidney (2000) J Urol, 164, pp. 1326-1328Borzi, P.A., Yeung, C.K., Selective approach for transperitoneal and extraperitoneal endoscopic nephrectomy in children (2004) J Urol, 171, pp. 814-816Guillonneau, B., Ballanger, P., Lugagne, P.M., Valla, J.S., Vallancien, G., Laparoscopic versus lumboscopic nephrectomy (1996) Eur Urol, 29, pp. 288-291Janetschek, G., Seibold, J., Radmayr, C., Bartsch, G., Laparoscopic heminephroureterectomy in pediatric patients (1997) J Urol, 158, pp. 1928-193

Luxación carpometacarpiana del primer dedo asociada a fractura de trapecio

Presentamos un caso de luxación carpometacarpiana del primer dedo asociada a fractura de trapecio. Fue tratada mediante reducción abierta y fijación interna. El resultado obtenido después de un año de seguimiento fue excelente. Sólo hemos encontrado once casos en la literatura y ninguno tratado como el nuestro.A case of carpometacarpal dislocation of the thumb associated with fracture of the trapezium in presented. It was treated by open reduction and internal fixation. The result after a one year follow-up was excellent. We have found only eleven cases in literature and none was treated like ours